Danish Husain has performed lead roles in plays by many of the best names in Indian theatre today, including Habib Tanvir, Rajinder Nath, M.K. Raina, Barry John, M.S. Sathyu, Sabina Mehta Jaitly and Sohaila Kapur. He is well remembered for his performances in the plays Manto, Panchi Aise Aate Hain, Jaat Hi Poocho Sadhu Ki, A Cat on A Hot Tin Roof, The Crucible, Mirzabagh, Agra Bazaar, and Rumi; Unveil The Sun. Husain received the Best Actor in A Supporting Role award for Rumi; Unveil The Sun at the Mahindra Excellence in Theatre Awards of 2008.

Danish has also performed in a British feature, Losing Gemma, for ITV. His current projects include acting assignments in two upcoming films, as well as documenting the making of one of the films with Academy Award nominee production house Aamir Khan Productions.

Since 2006, Husain has collaborated with his friend Mahmood Farooqui to revive a lost form of storytelling, Dastangoi. Their performances have been critically acclaimed. They will revisit Dastangoi with Naseeruddin Shah at the Muslim Voices: Arts & Ideas Festival in New York in June, 2009.

In addition to his work as an actor and performer, Husain is also a poet. His work has been published in Indian, Canadian and South African literary journals.